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โ† Trials
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Cohort of Prosthetic Joint Infections

Recruitingn/aAges 18 Years - anyAllGroupe Hospitalier Diaconesses Croix Saint-Simon
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In plain words

What the trial is, and whether it could suit you

Management of prosthetic joint infections (PJI) is a challenging task. These infections include different clinical and microbiological settings calling upon various treatment strategies according to infection type (acute or chronic), bone quality, the involved micro-organism and the patient's general condition and willing. Treatment of PJI combines surgery and prolonged antibiotic therapy. In some patients with a high operative risk prolonged suppressive antibiotic therapy can be used. Lack of large prospective studies motivated the conception of this cohort with a long term follow up, regardless to PJI management procedures.

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Patient aged over 18 years old with hip, knee and or shoulder joint prosthesis who consented to participate in the study with: * According to musculoskeletal infection society definition: PJI is present when one of the major criteria exists or four out of six minor criteria. Major Criteria: * Two positive periprosthetic cultures with phenotypically identical organisms, OR * A sinus tract communicating with the joint, OR Minor Criteria: * Elevated serum C-reactive protein (CRP) AND erythrocyte sedimentation rate (ESR) * Elevated synovial fluid white blood cell (WBC) * Elevated synovial fluid polymorphonuclear neutrophil percentage (PMN%) * The presence of pus in the joint without known cause * Positive histological analysis of periprosthetic tissue * A single positive culture Or a PJI which meets the following three criteria: * Medical story suggesting prosthetic joint infection. * The presence of pain either with or without swelling for more than 3 months unrelated to a mechanical cause. * Germ identification in a single sample of fluid aspiration or tissue culture. * Or microbial growth in prosthesis sonication fluid culture greater than 50CFU/ml. Exclusion Criteria: * Patient who does not meet eligibility criteria. * Patient lawfully deprived of his liberty. * Patient not insured under social security scheme.
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What it tests

  • Not listed
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Where

1 site
Groupe Hospitalier Diaconesses Croix Saint Simon
Paris, France
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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