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Therapeutic Effects of R-IDARAM and Intrathecal Immunochemotherapy on Elderly Patients With PCNSL

RecruitingPhase 2, Phase 3Ages 60 Years - 75 YearsAllNavy General Hospital, Beijing
NCT02836158 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This study suggests that R-IDARAM combined with intrathecal immunochemotherapy may be high effective in elderly patients with primary central nervous system lymphoma (PCNSL).

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📋 Eligibility rules (as published)
Inclusion Criteria: * Newly diagnosed histologically proven non-Hodgkin's lymphoma (NHL). Exclusion Criteria: * Involved sites other than the brain, meninges, CSF, or the eyes. * Age less than 18 years or greater than 75 years. * Inadequate bone marrow capacity (defined as neutrophils\<1.5 ×10\^9/L, platelets \<100 ×10\^9/L, and hemoglobin level\< 8 g/dL). * Known cause of immunosuppression (ie, HIV type I infection). * Any previous malignancy. * Creatinine clearance below 60 mL/min. * Heart insufficiency (NYHA IIIB or IV). * Uncontrolled infection. * Noncompensated active pulmonary or liver disease. * Previously treated for PCNSL, except by corticosteroids.
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What it tests

  • R-IDARAM plus intrathecal chemotherapy
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Where

1 site
Navy General Hospital
Beijing, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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