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HDClarity: a Multi-site Cerebrospinal Fluid Collection Initiative to Facilitate Therapeutic Development for Huntington's Disease

Recruitingn/aAges 11 Years - 75 YearsAllUniversity College, London
NCT02855476 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

HDClarity will seek at least 2500 research participants at different stages of Huntington's disease (HD). The primary objective is to collect a high quality CSF sample for evaluation of biomarkers and pathways that will enable the development of novel treatments for HD. The secondary objective is to generate a high quality plasma sample collection matching the CSF collections, which will also be used to evaluate biomarkers and pathways of relevance to HD research and development.

Sign in to get the eligibility rules as simple questions to take to your doctor.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age (18-75 years controls, early/late premanifest HD and incomplete penetrance HD, 21-75 years early/moderate/advanced manifest HD, ≥11 years juvenile HD) * Enroll HD participant * Capable of consenting or have a legal representative (parent/guardian for juveniles) * Capable of complying with study procedures * All participants other than family and community controls must have had a genetic test for HD Exclusion Criteria: * Drug trial within 30 days of any sampling visit * Changes in medication (antidepressant, psychoactive, psychotropic or other medications or nutraceuticals used to treat HD within 30 days) * Antiplatelet or anticoagulant therapy within 14 days * Significant comorbidity * Needle phobia, headache, spinal surgery / deformity * Clotting or bruising disorder * Screening blood test abnormalities \>10% outside normal range * Drug / alcohol abuse * Positive urine pregnancy test at any screening or sampling visit for females of childbearing potential * Predictable non compliance or unwillingness * Serious adverse event related to HDClarity study procedures or any lumbar puncture procedure performed for any reason in the previous 30 days
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What it tests

  • Not listed
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Where

40 sites
Cenexel
Englewood, United States
Georgetown University
Washington D.C., United States
John Hopkins University
Baltimore, United States
Wake Forest University
Winston-Salem, United States
Vanderbilt University Medical Center
Nashville, United States
University of Texas Health Science Center
Houston, United States
University of British Columbia, The Centre for Huntingtons Disease
Vancouver, Canada
The Ottawa Hospital
Ottawa, Canada

…and 32 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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