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Bariatric Surgery and Pharmacokinetics of Amlodipine

Recruitingn/aAges 18 Years - 70 YearsAllNorwegian University of Science and Technology
NCT02904291 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Changes to gastric pH, gastric emptying time, gastrointestinal transit-time or the pre-systemic metabolizing effect of enzymes secreted in the mucosa may all alter the pharmacokinetics of medicines. These factors are potentially influenced by bariatric surgery. Little is so far known about how gastric bypass and sleeve gastrectomy impacts the biological availability of medication. In this study we investigate the pharmacokinetic effects of bariatric surgery on amlodipine.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Preparing to undergo gastric bypass or sleeve gastrectomy in Central Norway * Being a Norwegian citizen Exclusion Criteria: * Having previously undergone resections in the GI-tract
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What it tests

  • Amlodipine
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Where

1 site
St. Olavs University Hospital
Trondheim, Norway
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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