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Ontario-wide Cancer TArgeted Nucleic Acid Evaluation

Recruitingn/aAges 18 Years - anyAllUniversity Health Network, Toronto
NCT02906943 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Substantial progress has been made in the treatment of cancer through the use of targeted therapies, but what works for one patient might not work for another patient. Certain drugs are now being developed that target specific molecules in the body that are believed to be part of the disease. Biomarkers are specific characteristics of the cancer that may help provide prognostic information (e.g. how well patients will be regardless of the treatments given) or help predict sensitivity or resistance to a specific treatment. The study will collect archival tumor samples (previously collected biopsy or surgical tumor samples) to provide biomarker data about a patient's cancer, which may help their physicians to identify which clinical trials of new drug treatments may be most appropriate for the patient in the future and may also guide the use of approved treatments that may potentially be

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Patients with histological confirmation of advanced solid tumor malignancies who are candidates for systemic therapy. 2. All patients must have sufficient FFPE archived tumor tissue for molecular profiling. 3. Patient must be ≥ 18 years old. 4. Patient's ECOG performance status equal to 0 or 1. 5. All patients must have a life expectancy of \> 6 months. 6. All patients must have adequate organ functions. 7. All patients must have signed and dated an informed consent form. Exclusion Criteria: 1\. Patients must not have received more than 2 lines of prior cytotoxic therapy for their recurrent/metastatic disease, with the exception of Phase I trial candidates who will not be excluded if more than 2 lines of prior cytotoxic therapy have been received.
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What it tests

  • Not listed
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Where

7 sites
Juravinski Cancer Centre
Hamilton, Canada
Kingston General Hospital
Kingston, Canada
London Health Sciences Centre
London, Canada
The Ottawa Hospital Cancer Centre
Ottawa, Canada
Princess Margaret Hospital
Toronto, Canada
Mount Sinai Hospital
Toronto, Canada
Sunnybrook Health Sciences Centre
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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