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Oedema Study : Chroedem

Recruitingn/aAges 18 Years - 99 YearsAllUniversity Hospital, Montpellier
NCT02914808 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The chroedem study is aiming to assess tissue and biomolecular components of chronic lower limb oedema (CO). The investigators working hypothesis is that according to the aetiology of CO, the proportion of oedema \& composition of peri-oedema tissues (fat, muscle, fibrosis/inflammation) might differ and could at least in part explain differences in failure/success of compressive therapies from one patient to another. For that purpose, 24 patients with a post-thrombotic syndrome (PTS)-related oedema and 24 patients with a primary lymphedema will undergo a magnetic resonance imaging (MRI)) of the legs and biological (genetic) testing.

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📋 Eligibility rules (as published)
Inclusion criteria: * Lower limb CO secondary to PTS or Primary lymphoedema (We will include secondary lymphedema of the lower limbs only if the matcing constraints on age and length of evolution do not allow pairing) Exclusion criteria: * Bilateral CO * Obesity * Mixed CO (PTS and lymphatic origins) * CO of other origin : Heart failure, hepatic or renal impairment * Denutrition * Contra-indication to MRI * Patient not affiliated to French Health Insurance System * Patient protected by the law * Patient refusing to participate
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What it tests

  • Patients will undergo a lower limb MRI and blood tests
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Where

3 sites
Pr Sophie BLAISE
Grenoble, France
University Hospital of Montpellier
Montpellier, France
University Hospital Nimes
Nîmes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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