Therapeutic Effects of Hydrogen on Steroid-refractory/or Steroid-dependent cGVHD

Inclusion Criteria: * Written informed consent * Male * not pregnant female * patients \<65 years old * Diagnosis of cGVHD steroid refractory (no response after Prednisone ≥1mg/kg ) or steroid-dependent cGVHD (had an initial response followed by a cGVHD flare upon steroid taper) * Patient intolerant to steroid therapy Exclusion Criteria: * Patients with stable disease, not well controlled by the current treatment * Pregnancy * HIV positive * Severe liver or renal impairment: serum creatinine \>2.5 mg/dl; serum bilirubin\>2.5 mg/dl (without evidence of hepatic cGVHD) * Uncontrolled malignancies including the persistence of the underlying malignancy before the Allogeneic Transplantation and the relapse of hematopoietic malignancy * Any other investigational agents administered within last four weeks * Cardiac insufficiency (\>grade II, New York Heart Association classification) * Inability to comply with medical therapy or follow-up