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Impact of Complete Surgery of Colorectal Deep Infiltrating Endometriosis on Fertility

RecruitingNAAges 18 Years - 38 YearsFemaleUniversity Hospital, Lille
NCT02948972 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The ENDOFERT Study is an open, multicenter, randomized, parallel-group, controlled trial. This study includes patients presenting colorectal DIE and infertility. Patients will be randomized in two parallel-groups; one group underwent complete surgery of colorectal DIE prior to ART and the other group underwent ART alone (ratio 1:1)

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📋 Eligibility rules (as published)
Inclusion Criteria: * Primary and secondary infertility * Indication for IVF * Persistent pain related to endometriosis with analgesic medical treatment failure * Persistent pain including at least one of the following digestive symptoms related to endometriosis: Dyschesia / Sub-occlusive syndrome / Rectal bleeding / Painful defecation * Colorectal deep infiltrating endometriosis : Whatever lesion size / With at least rectal serosal involvement / Confirmed by MRI and 1 different investigation: vaginal ultrasound echography or coloscopic CT scan or rectal endoscope ultrasound * Eligible for DIE surgery Exclusion Criteria: * Contraindication to pregnancy or to IVF * Viral risk * Previous IVF cycle(s) * Previous colorectal surgery * Need of myomectomy during surgery * The use of oocytes donor
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What it tests

  • complete surgery
  • In vitro fertilization without surgery
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Where

5 sites
CHU
Clermont-Ferrand, France
Hôpital Jeanne de Flandres, CHRU
Lille, France
AP-HP, Hôpital Tenon
Paris, France
CHU
Poissy, France
CHU
Rouen, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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