AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Annuloplasty for Not-Severe TR in Patients Undergoing MV Repair Versus Mitral Repair Only (NOSTRUM)

RecruitingNAAges 18 Years - anyAllOspedale San Raffaele
💬

In plain words

What the trial is, and whether it could suit you

The surgical treatment of less than severe (≤2+/4+) functional tricuspid regurgitation (TR) in patient undergoing mitral valve surgery, is still controversial: some observational studies have suggested that performing tricuspid annuloplasty in patients undergoing mitral valve surgery with a dilated tricuspid annulus, and TR≤2+ may provide a clinical benefit, while in other observational studies such benefit has not been documented. The ESC Guidelines assign the class IIa recommendation for surgical treatment in patients with tricuspid regurgitation ≤2+ and a dilated annulus, if surgery is concomitant to the repair or replacement of the mitral valve. However the level of evidence C (expert opinion) confirms the absence of clear scientific evidence to support this recommendation. It is therefore very important to carry out randomized trials designed to really prove the supposed efficacy

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * age \> 18 years; * ability to provide informed consent; * patients scheduled for mitral valve regurgitation * TR ≤ 2+ with annular dilation * Tricuspid diastolic diameter ≥ 40 mm or 21 mm/m2 Exclusion Criteria: * patient's refusal * non-elective cardiac surgery; * organic disease of tricuspid valve * TR≥3
💊

What it tests

  • M & T Repair Group
  • Mitral-Only Group
📍

Where

3 sites
Istituto Clinico Humanitas
Rozzano, Italy
IRCCS Ospedale San Raffaele
Milan, Italy
Central Clinical Hospital of the Ministry of Internal Affairs and Administration, Warsaw, Poland
Warsaw, Poland
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy