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High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease

RecruitingNAAges 40 Years - anyAllUnity Health Toronto
NCT03033251 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide. The disease is marked by multiples episode of worsening, termed exacerbations necessitating frequent hospitalizations. During these exacerbations, patients present breathless, and in the most severe cases, are admitted to an Intensive Care Unit (ICU) for respiratory assistance. Currently, respiratory assistance is provided by a ventilator via a oronasal mask (referred to non-invasive ventilation, NIV), that helps patients to cope with their breathless. The mask is not always well tolerated and the ventilator sessions are delivered intermittently. In the past decade, a new technique that provides air-oxygen with high flow has been developed. This technique, called High Flow via Nasal Cannula (HFNC) can deliver from 21

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. COPD exacerbation and acute hypercapnic respiratory failure with acute respiratory failure defined by * Respiratory acidosis (pH ≤7.35 and PaCO2 ≥45 mmHg); * Respiratory rate≥20 breaths/min; * Activation of accessory respiratory muscles; 2. Undergone at NIV or HFNC since their admission 3. English speaking 4. Adult patient with age \> 40 year old. Exclusion Criteria: 1. Severe respiratory acidosis defined by pH\<7.25 2. Decreased level of consciousness (Glasgow Coma Score Scale \< 11) 3. Urgent intubation required 4. Pneumothorax with pleural drainage and persistent air leak 5. Hemodynamic instability requiring vasopressors 6. Uncooperative 7. Patients with skin or chest wall or abdominal trauma (potentially worsened by placement of a surface sensor) 8. Clinical judgement of the attending physician 9. Body mass index \> 40 kg/m2
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What it tests

  • Non Invasive Ventilation
  • High Flow Oxygen Cannula 50
  • High Flow Oxygen Cannula 30
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Where

1 site
St. Michael's Hospital
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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