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Overnight Trials With Heat Stress in Autonomic Failure Patients With Supine Hypertension

RecruitingNAAges 18 Years - 80 YearsAllVanderbilt University Medical Center
NCT03042988 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Patients with autonomic failure are characterized by disabling orthostatic hypotension (low blood pressure on standing), and at least half of them also have high blood pressure while lying down (supine hypertension). Exposure to heat, such as in hot environments, often worsens their orthostatic hypotension. The causes of this are not fully understood. The purpose of this study is to evaluate whether applying local heat over the abdomen of patients with autonomic failure and supine hypertension during the night would decrease their nocturnal high blood pressure while lying down. This will help us better understand the mechanisms underlying this phenomenon, and may be of use in the treatment of supine hypertension.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Male and female patients, between 18-80 yrs., with primary autonomic failure (Parkinson Disease, Multiple System Atrophy, and Pure Autonomic Failure) and supine hypertension. Supine hypertension will be defined as SBP≥150 mmHg. * Patients able and willing to provide informed consent. Exclusion Criteria: * Pregnancy * Significant cardiac, renal or hepatic illness, or with contraindications to administration of pressor agents or with other factors, which in the investigator's opinion would prevent the subject from completing the protocol including clinically significant abnormalities in clinical, mental or laboratory testing.
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What it tests

  • Heating pad
  • Sham control
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Where

1 site
Autonomic Dysfunction Center/ Vanderbilt University Medical Center
Nashville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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