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Seizure Treatment in Glioma

RecruitingPhase 4Ages 18 Years - anyAllLeiden University Medical Center
NCT03048084 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Currently, treatment with a specific anti-epileptic drug mainly depends on the physicians' preference, as there are no studies supporting the use of one specific anticonvulsant in glioma patients. The overall aim of this randomized controlled trial is to directly compare the effectiveness of treatment with levetiracetam or valproic acid in glioma patients with a first seizure.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histologically proven or suspected diffuse astrocytoma (Isocytrate Dehydrogenase-1 (IDH-1) wildtype or IDH-1 mutated), diffuse oligodendroglioma (IDH-1 mutated and 1p/19q co-deleted), anaplastic astrocytoma (IDH-1 wildtype or IDH-1 mutated), anaplastic oligodendroglioma (IDH-1 mutated and 1p/19q co-deleted), glioblastoma (IDH-1 wild-type or IDH-1 mutated), or diffuse astrocytoma not otherwise specified (NOS), anaplastic astrocytoma NOS, oligodendroglioma NOS, oligoastrocytoma NOS, anaplastic oligoastrocytoma NOS, anaplastic oligodendroglioma NOS or glioblastoma NOS. * Adult patients: ≥18 years of age * First epileptic seizure, no longer than 2 weeks ago * Monotherapy with antiepileptic drugs is considered most appropriate at the time of randomization * Willing to provide written informed consent Exclusion Criteria: * Previously treated with antiepileptic drugs, except emergency treatment in the past 2 weeks * History of non-brain tumor related epilepsy * Pregnancy * Presence of contra-indications for use of levetiracetam or valproic acid
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What it tests

  • Levetiracetam
  • Valproic Acid
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Where

5 sites
Amsterdam UMC
Amsterdam, Netherlands
Medisch Spectrum Twente
Enschede, Netherlands
Leiden University Medical Center
Leiden, Netherlands
Erasmus Medical Center
Rotterdam, Netherlands
Haaglanden Medical Center
The Hague, Netherlands
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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