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Screening for Anal Cancer in Women With High-grade Vulvar Dysplasia or Vulvar Cancer.

RecruitingNAAges 40 Years - anyFemaleDr. Danielle Vicus
NCT03061435 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Almost half of all women will develop an HPV infection in their lifetime. While most infections are naturally asymptomatic or cleared by the immune system, some persist and can lead to the development of cervical, vulvar, or anal lesions and eventually cancer. Screening regimens for these lesions are currently only in place for the cervix through regular Pap tests. These Pap tests usually involve an examination of the vulva -however, no screening procedures exist for anal cancer for women. Several studies have suggested that women with existing gynecological lesions are more likely to develop anal lesions and anal cancer. Here the investigators propose a multi-center study which seeks to screen for and treat anal cancer in women over the age of 40 with vulvar lesions and a stable immune system. The investigators will achieve this through performing anal Pap smears on eligible women and c

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women age ≥ 40 * Previous diagnosis of VIN 2/3 or vulvar Exclusion Criteria: * Women with a previous diagnosis of cancer aside from basal cell carcinoma of the skin, cervical cancer, or vulvar cancer * Women who are HIV positive * Women currently taking immunosuppressant medication * Women who have had a previous hysterectomy
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What it tests

  • Screening anal Pap smear - No high-resolution anoscopy
  • Screening anal Pap smear - High-resolution anoscopy
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Where

1 site
Odette Cancer Centre
Toronto, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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