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Mechanisms of Malnutrition in Cirrhosis With Portosystemic Shunting

Recruitingn/aAges 18 Years - 70 YearsAllThe Cleveland Clinic
NCT03121404 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Cirrhosis is characterized by loss of muscle as well as fat mass, which increases morbidity and mortality before, during, and after liver transplantation. A common mechanism for the reduced muscle and fat mass in cirrhosis is an increased expression of the TGF (transforming growth factor)beta superfamily member, myostatin, in the muscle and adipose tissue. The present study will examine the expression of myostatin, its receptor and intracellular signaling pathways in the skeletal muscle and mesenteric adipose tissue in cirrhotic patients undergoing liver transplantation as compared to healthy controls undergoing planned abdominal surgery. 16 cirrhotic patients will be identified from the transplant list, and 16 healthy controls from outpatient surgery lists. Nutritional assessment will be performed, including anthropometry (triceps skinfold thickness, mid arm circumference), dual energy

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age 18-70 years * Patients undergoing abdominal surgery (liver transplantation or other surgery) Control 1. non liver transplant donor 2. Elective abdominal surgery (cholecystectomy, diverticulosis, acute gastrointestinal bleeding in the absence of exclusion criteria) Exclusion Criteria: * Exclusion criteria (all subjects) * Average daily alcohol intake \> 20 g in women and \> 30 g in men * Diabetes or a fasting serum glucose \> 100 mg/dL * Hyper- / hypo- thyroidism * Renal disease with serum creatinine \> 1.4 mg/dL * Folate or vitamin B12 deficiency * Active intravenous drug use * History of bowel surgery or gastric bypass surgery * Medications/supplements that affect fat mass or protein mass (creatine, glucocorticoids) * Pregnancy * Chronic diseases that result in cachexia (renal, cardiac, pulmonary, hematologic, cancer) * Hepatocellular cancer Exclusion criteria (controls) * Evidence of malnutrition as quantified by triceps skinfold thickness, mid arm muscle area and creatinine height index)
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What it tests

  • Rectus abdominis muscle biopsy
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Where

1 site
Cleveland Clinic Foundation
Cleveland, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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