AI Cure is a research tool showing open data. Not medical advice. Discuss with your doctor. Terms

← Trials
🧪

Immunogenicity and Safety of the Yellow Fever Vaccine in HIV Infected Individuals

RecruitingPhase 4Ages 18 Years - 59 YearsAllOswaldo Cruz Foundation
💬

In plain words

What the trial is, and whether it could suit you

Phase 4 study to evaluate the immunogenicity and Safety of the 17DD Yellow Fever vaccine in HIV infected individuals, compared to non-HIV-infected individuals. Main objective: To compare the proportion of seroconversion and the geometric mean of neutralizing antibodies 30 days and 365 days after vaccine. Secondary objectives: To evaluate whether the titles of neutralizing antibodies are associated with CD4 lymphocyte counts, CD8 lymphocyte counts, CD4 nadir, HIV viral load and use of antiretroviral therapy. To assess the yellow fever vaccine viremia at day 10 after vaccine.To compare the incidence of adverse events in HIV-infected and non-HIV-infected individuals.

Sign in to get the eligibility rules as simple questions to take to your doctor.

📋 Eligibility rules (as published)
Inclusion Criteria: * HIV infected adults, age \>= 18 and \<60 years old. * CD4 \> 200 cells/mm³ within the last 6 months prior to inclusion. Individuals with no CD4 results in the last 6 months which have undetectable HIV viral load and last CD4 count \> 350 can be included. * Healthy HIV-uninfected individuals (aged \>= 18 and \< 60) * No history of Yellow Fever vaccination * Willing to participate and to sign the consent Exclusion Criteria: * Individuals with chronic diseases such as: decompensated diabetes, kidney failure (in dialysis), liver failure/cirrhosis, cancer (except for non-melanoma skin cancer and in situ HIV related carcinoma), use of immunosuppressive agents (including prednisone ≥ 20mg/day, during 7 or more days in the last 30 days before inclusion). * Pregnant women * Hypersensitivity reaction to eggs, chicken protein. Allergy to erythomycin or kanamycin. Hereditary fructose intolerance. * Administration of immunoglobulins or blood derivates \< 3 months or life attenuated vaccine \<1 month. * History of thymic dysfunction (including thymoma and thymectomy). * Use of anti-CCR5 * symptoms of severe acute illnesses or fever (axillary temperature ≥ 38°C) * HIV positive rapid test for HIV negative subjects.
💊

What it tests

  • Yellow Fever vaccination (17 DD Biomanguinhos)
📍

Where

1 site
Instituto Nacional de Infectologia Evandro Chagas
Rio de Janeiro, Brazil
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
🛡️

AI Cure shows public evidence (Open Targets, ClinicalTrials.gov, PubMed, openFDA, DepMap, AlphaFold) with its source, and AI summaries that cite it — not medical advice and not a cure. Treatment decisions belong with your doctor. Research ideas are shared only with approved researchers and labs, who can test them. In an emergency call your local emergency number (112 in India and Europe, 911 in the US). AI Cure Terms of Use · Privacy