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Multi-Institutional Registry for Malignant Peripheral Nerve Sheath Tumors

Recruitingn/aAges any - anyAllWashington University School of Medicine
NCT03141021 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

First, the investigators plan to use a retrospective analysis to determine the clinical landscape of neurofibromatosis (NF)1-associated malignant peripheral nerve sheath tumor (MPNST) and precursor lesions (e.g., atypical or nodular plexiform neurofibromas). A worldwide database will be established, collecting, in a standardized manner, histologic, immunohistochemical, molecular, radiographic, treatment, and related clinical data from centers worldwide with expertise in these NF1-related cancers. Although retrospective in nature, the resulting data from this registry may reveal previously unanticipated patterns, similar to the INFACT effort outcome. This registry would then allow the acquisition of data associated with MPNST biospecimens collected under associated banks (frozen or paraffin-embedded, germline (or normal tissue DNA) samples, and any previously somatic whole-exome or whole-

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📋 Eligibility rules (as published)
Inclusion Criteria and Exclusion Criteria: -Any patient diagnosed with an MPNST is eligible for enrollment to this registry provided s/he consents to participate (or consent form his/her parent or legal guardian or legally authorized representative is obtained).
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What it tests

  • Not listed
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Where

13 sites
Moffitt Cancer Center
Tampa, United States
Johns Hopkins
Baltimore, United States
National Institutes of Health (NIH)
Bethesda, United States
Dana Farber Cancer Institute
Boston, United States
University of Minnesota
Minneapolis, United States
Washington University School of Medicine
St Louis, United States
Memorial Sloan Kettering Cancer Center
New York, United States
Lifespan
Providence, United States

…and 5 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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