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Electrophysiological Source Imaging Guided Transcranial Focused Ultrasound

RecruitingNAAges 18 Years - 64 YearsAllCarnegie Mellon University
NCT03192436 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Neuromodulation is a fast growing field that offers a wide range of applications for both understanding and treating the brain. Future research for non-invasive neuromodulation will need to elucidate the optimal frequency, duration, and intensity of stimulation for a variety of technologies and diseases. Closed loop stimulation is thus a promising research area that allows for responsive stimulation and real time symptom management. Our project is proposed to develop and test a novel noninvasive neuromodulation integrating transcranial focused ultrasound stimulation (tFUS) with electrophysiological source imaging (ESI-tFUS) to allow evidence-based neuromodulation for brain research and the management of brain conditions. Despite the recent developments and attention surrounding tFUS, relatively little is known about the mechanisms and optimal parameters of this stimulation technology. Th

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📋 Eligibility rules (as published)
Inclusion Criteria: * Apparently healthy volunteers. * Age 18-64. * Willing and able to provide written consent. * Able to communicate in the English language. Exclusion Criteria: Subjects having any of the following conditions will be excluded from this study: * Evidence of a current significant medical illness or psychiatric or central or peripheral neurologic disorder * History of loss of consciousness of more than ten minutes in the past year or loss of consciousness in a lifetime that required rehabilitation services * Personal or family history of seizure * Any history of stroke/transient ischemic attack (TIA) * Taking any medications that are known to decrease the threshold for seizure * Pregnancy * Affirmative answers to one or more questions of the provided attached safety questionnaires. These are not absolute contraindications to this study but the risk/benefit ratio will be carefully considered by the PI * Failure to follow laboratory or study procedures
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What it tests

  • Ultrasound
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Where

1 site
Department of Biomedical Engineering, Carnegie Mellon University
Pittsburgh, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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