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Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass

RecruitingNAAges 18 Years - 90 YearsAllUniversity of Colorado, Denver
NCT03204357 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Autologous blood transfused at the end of cardiopulmonary bypass will reduce total blood loss 24 hours after surgery and improve mitochondrial oxygen delivery measured by plasma succinate levels. The study design is a prospective randomized interventional trial of transfusion of fresh autologous whole blood versus standard of care expectant management of bleeding during elective cardiac surgery.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Adult subjects aged 18 to 90 2. Able to provide informed consent 3. Willing to accept autologous or allogenic blood transfusion 4. Scheduled for elective cardiac surgery with cardiopulmonary bypass Exclusion Criteria: 1. Pre-operative administration of allogenic blood bank products in the previous 3 months 2. Hemodynamically unstable defined as a systolic blood pressure less than 90 mmHg with a heart rate greater 100 or requiring intravenous vasopressor medications 3. Significant active infection or sepsis defined by positive blood culture or positive wound culture 4. Hemoglobin less than 7 g/dl
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What it tests

  • Fresh Autologous whole Blood
  • Standard of Care Expectant management of bleeding
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Where

1 site
University of Colorado Hospital
Aurora, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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