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The preSPG4 Study - Studying the Prodromal and Early Phase of SPG4

RecruitingNAAges 18 Years - 70 YearsAllUniversity Hospital Tuebingen
NCT03206190 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Study goals 1. Prospective longitudinal data on progression in the natural course of SPG4 in presymptomatic mutation carriers prior to clinical disease onset and in early stages of disease 2. Biomarkers providing objective measures of disease activity

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📋 Eligibility rules (as published)
Inclusion Criteria: * First degree relatives (parents, offspring, and sibs) of SPG4 patients or symptomatic individuals with known SPAST mutation * Age 18 to 70 years * Written, informed consent (patient) Exclusion Criteria: * No known SPAST-mutation within the family * Manifest spastic gait (subclinical signs like increased deep tendon reflexes, positive Babinski sign are allowed) * Participation in interventional trials
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What it tests

  • SPRS Score and clinical signs
  • Cognition Testing using CANTAB
  • Lumbar Puncture and blood draw
  • MRI
  • Electrophysiology
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Where

1 site
University Hospital Tübingen, Center for Neurology
Tübingen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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