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Biomarkers of Synaptic Damage in Multiple Sclerosis

Recruitingn/aAges 18 Years - 65 YearsAllNeuromed IRCCS
NCT03217396 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

A prospective and retrospective cohort study of about five years will be performed on blood and cerebrospinal fluid samples taken for diagnostic reasons from recruited patients within the Neuromed Neurology Unit. Subjects with other chronic neurodegenerative diseases such as Amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD), and healthy subjects subjected to blood sampling and / or lumbar puncture for clinical reasons will be recruited As control groups.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Male and female patients (age between 18 and 65 years) 2. Diagnosis of MS in accordance with McDonald's (2010 rev) criteria, 3. EDSS between 0 and 5.5 (included), 4. Patients able to provide informed consent to participation in the study Exclusion Criteria: 1. Inability to provide informed written consent 2. Altered basal blood count 3. Pregnancy or lactation 4. Contraindications for the execution of magnetic resonance imaging with gadolinium 5. Significant clinical conditions in addition to SM or other chronic neurodegenerative diseases including latent viral infections
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What it tests

  • lumbar puncture
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Where

1 site
IRCCS Neuromed
Pozzilli, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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