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Novel Tracer Methods to Evaluate Muscle Protein Metabolism in Cirrhosis

Recruitingn/aAges 18 Years - anyAllThe Cleveland Clinic
NCT03225677 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

To determine the rate and mechanisms of skeletal muscle protein synthesis and breakdown in cirrhotic patients by using multiple tracers and single muscle biopsies.

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📋 Eligibility rules (as published)
Inclusion Criteria: * The diagnosis of cirrhosis based on liver biopsy and/or clinical, biochemical, and imaging criteria. * Patients with Child Pugh score from A5- to B7 * Control group: Subject in control group should have serum ALT and AST within normal range. Exclusion Criteria for both groups (cirrhotic and control) are: * diabetes * cancer * kidney failure * pregnancy * recent surgery (bowel resection or Gastric bypass operation) * Advanced cardiac or pulmonary disease * patient with thyroid disease \& Coagulopathy ( INR \>1.4 and platelet count \<80,000/ml)
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What it tests

  • blood draw and muscle biopsy
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Where

1 site
Cleveland Clinic Foundation
Cleveland, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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