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Radiation Therapy or Chemoradiation, Interstitial Brachytherapy in Combination With Hyperthermia in Advanced Cervical Cancer

RecruitingNAAges 18 Years - anyFemaleUniversity of Erlangen-Nürnberg Medical School
NCT03249519 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The combination of radiation therapy or chemoradiation with Interstitial brachytherapy for advanced cervical cancer (pN+, FIGO-Stage II B - IV A is standard of therapy. The radio- and chemosensitive effect of an additional hyperthermia might improve the clinical outcome.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Histological confirmed carcinoma of the Cervix * FIGO-Stage IIB-IVA; earlier stages when inoperable or according to patient's wish * clinical M0; except: involvement of para-aortic lymph nodes * Age ≥ 18 years * ECOG ≤ 2 * Informed consent of the patient Exclusion Criteria: * Pre-existing uncontrolled cardiac disease, signs of cardiac failure, or rhythm disturbances requiring therapy * Cardiac Pacemaker * Myocardial infarction within the past 12 months * Congestive heart failure * Complete bundle branch block * New York Heart Association (NYHA) class III or IV heart disease * Disease that would preclude chemoradiation or deep regional hyperthermia * Metal implants (length \> 2cm or dense clusters of marker clips in the pelvis) * Active or therapy-resistent bladder infections * Pre-existing or concommitant immunodeficiency Syndrome * Pregnant or lactating women * Patients not willing to use effective contraception during and up to 6 months after therapy
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What it tests

  • Radiation
  • brachytherapy
  • Cisplatin
  • Hyperthermia
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Where

1 site
Universitätsklinikum Erlangen, Strahlenklinik
Erlangen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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