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Dynamics of Platelet Activation in Patients With Ventricular Assist Device (VAD)

Recruitingn/aAges 18 Years - 75 YearsAllScientific Institute San Raffaele
NCT03255928 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Consenting patients with end-stage heart failure that are implanted with/candidates for implant of a short-term/durable mechanical circulatory support device (e.g.: percutaneous microaxial pumps (Impella), extracorporeal membrane oxygenator (ECMO), Ventricular Assist Device (VAD) will be enrolled in the study. Aim of the study is to evaluate the patients' haemostatic and coagulation profile, how it interacts with the support device as well as the effect of antithrombotic drugs. From these data, it will be possible to derive the mechanisms triggering post-implant thromboembolic/hemorrhagic complications and to identify potential therapeutic targets.

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📋 Eligibility rules (as published)
Inclusion Criteria: * All consenting patients candidates for short-term (Impella, ECMO) or durable (LVAD) mechanical circulatory support device implantation * All consenting patients that are implanted with short-term (Impella, ECMO) or durable (LVAD) mechanical circulatory support device Exclusion Criteria: \- Patients \< 18-years old
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What it tests

  • PAS assay, TGT
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Where

1 site
San Raffaele Scientifc Institute - Cardiothoracic Intensive Care Unit
Milan, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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