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Thrombus Composition in Ischemic Stroke: Analysis of the Correlation With Plasma Biomarkers, Efficacy of Treatment, Etiology and Prognosis

Recruitingn/aAges 18 Years - anyAllFondation Ophtalmologique Adolphe de Rothschild
NCT03268668 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The recent validation of thrombectomy in addition to thrombolysis with intravenous administration of alteplase suggests a major revolution in the management of acute strokes. This treatment option also opens up a new field of research, making possible the analysis of the clot responsible for intracranial occlusion. Indeed, in about 30% of the cases, the thrombectomy procedure makes it possible to retrieve either partially or completely the clot. Previous studies have analyzed the correlation between the composition of the thrombus and the etiology of stroke. Their discordant results do not yet make it possible to distinguish a particular profile of thrombus according to etiology. Other studies have shown a correlation between the proportion of red blood cells in a thrombus and the likelihood that it is visible in MRI or cerebral scanning. More recently, one study has demonstrated a corre

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients aged 18 years and older * Presenting with cerebral infarction following arterial occlusion * Treated for mechanical thrombectomy (whether performed or not) * Free, informed, and express consent of the patient or their relatives (emergency inclusion procedure) * For retrospective patients: thrombus already collected (according to the center's usual practice or for another research project). Exclusion Criteria: * Patient benefiting from a legal protection measure * Pregnant or breastfeeding woman
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What it tests

  • Collection of thrombus that is responsible for stroke and blood sample
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Where

12 sites
CHU de Bordeaux
Bordeaux, France
CHU Caen
Caen, France
Chu Limoges
Limoges, France
CHRU de Nancy
Nancy, France
CHU de Nantes
Nantes, France
Hôpital Lariboisière AP-HP
Paris, France
Centre hospitalier Sainte-Anne
Paris, France
Fondation Ophtalmologique A. de Rothschild
Paris, France

…and 4 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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