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Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits

RecruitingNAAges 16 Years - anyAllImperial College London
NCT03303547 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Any patient with a suspected primary adenocarcinoma of the colon, sigmoid or rectum undergoing surgery are eligible. The date of surgery must be known prior to registration. This trial aims to determine if image mapping techniques can improve the concordance between imaging and pathology detection of tumour deposits. Lymph nodes and tumour deposits will be identified on pre-operative scans and mapped by radiologists then shared with pathologists prior to processing the resected specimen. Patients will be managed at their local hospital with standard follow-up. Patients will be followed up for 5 years.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Suspected primary adenocarcinoma of the colon, sigmoid or rectum (proven by biopsy taken as part of routine clinical practice, patients to be withdrawn if not subsequently adenocarcinoma on pathology). 2. Amenable to surgical resection. 3. Disease spread assessed on imaging 4. Patients having primary surgery and those undergoing neoadjuvant treatment will be included. 5. All must have had baseline staging scans and those undergoing neoadjuvant therapy must also have had a post-treatment scan. 6. Patients aged 16 years and over Exclusion Criteria: 1. Patients with recurrent tumours 2. Synchronous tumours 3. Under the age of 16 years 4. Unable to give informed consent.
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What it tests

  • MRI mapping to guide pathological sampling of extranodal tumour deposits
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Where

1 site
Royal Marsden Hospital NHS Foundation Trust
London, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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