Three-dimensional Analysis of EMMPRIN on Conjunctival Epithelial Cells Surface in Severe Dry Eye Syndrome (ALTESSE)

Patients: Inclusion criteria * 18 years and over * Severe eye dryness (grade 3 or 4) as defined by the International Dry Eye Work Shop (2007): Frequent symptoms, Impregnation of fluorescein at the conjunctival level, marked fluorescein staining at the corneal level, Tear Break Up Time ≤ 5 seconds (fluorescein test) Schirmer's test score without anesthesia ≤ 5mm at 5 minutes * Patients without eye treatment or patients undergoing long-term stable eye treatment for whom a new treatment is being introduced Exclusion criteria - Known pregnancy or breastfeeding Control subjects: Inclusion criteria \- 18 years and over Exclusion criteria * Wearer of contact lenses * Topical ocular treatment * Known pregnancy or breastfeeding