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A Comparison of Four Different Treatment Regimens of Helicobacter Pylori in Chinese Children

RecruitingNAAges 6 Years - 18 YearsAllYing HUANG
NCT03365609 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

With the resistance of Helicobacter pylori increasing, low and unsatisfactory eradication rate (64%) have been observed with standard triple therapy in European children. Which regimen is appropriate for Chinese children? There is no large scale, multi center studies in China about treatment, CYP2C19 gene polymorphism, resistance rate and resistance genotype. Investigators want to perform a research to compare four different treatment regimens（triple therapy, sequential therapy, bismuth quadruple therapy and concomitant therapy）as the first-line treatment of Helicobacter pylori in Chinese children and investigation of resistance, impact factors and changes of microbiota after the therapy. The results of the study will provide theoretical basis to make the new guideline of diagnosis and therapy of Helicobacter pylori in Chinese children. It advance instruct and norm the clinical practice

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📋 Eligibility rules (as published)
Inclusion Criteria: * children 6-18 years of age who were referred for upper endoscopy and confirmed to have Hp infection Exclusion Criteria: * patients were excluded if they had taken proton pump inhibitors, H2-receptor antagonists or antibiotics in the 4 weeks prior to the study. Patients with known antibiotic allergy,hepatic impairment or kidney failure were also excluded. Patients who received Hp therapy before were also excluded.
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What it tests

  • triple therapy
  • sequential therapy
  • bismuth quadruple therapy
  • concomitant therapy
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Where

1 site
Children's hospital of Fudan university
Shanghai, China
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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