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Mechanistic Clinical Trial of Advanced Imaging for CRT

RecruitingNAAges 20 Years - 90 YearsAllUniversity of Virginia
NCT03398369 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Chronic systolic HF 2. LVEF 35% or less 3. Guideline-based class I or II indication for CRT Exclusion Criteria: 1. Inability to provide informed consent 2. Pregnancy 3. Presence of metal embedded in the body due to prior accident or injury, as documented by skull films or other imaging 4. Cerebral aneurysm clips 5. Cochlear implants 6. Other metallic implants known to be contraindications to CMR (does not include pacemakers and ICDs) 7. Severe claustrophobia 8. Acute kidney injury 9. Acute renal failure or chronic kidney disease with GFR \< 45 cc/min/1.73m2 10. Liver transplant 11. Gadolinium allergy 12. \>10% premature ventricular contraction (PVC) burden; and 13) estimated \>10% atrial fibrillation (AF) burden based on available clinical data.
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What it tests

  • CMR/CTA Guidance for CRT
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Where

1 site
University of Virginia Health System
Charlottesville, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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