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Biology of Juvenile Myoclonic Epilepsy

Recruitingn/aAges 10 Years - 40 YearsAllKing's College London
NCT03400371 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The investigators are collecting genetic information through blood samples as well as clinical and EEG data from over 1000 people with Juvenile Myoclonic Epilepsy (JME) across the UK, Europe and North America. This study will draw on both existing and new samples from JME patients. These will be compared to anonymised data from samples for 2000 controls. The goal of this study is to find the genetic cause of JME. Finding the cause will help create better treatments for JME, as well as improve patient outcomes by allowing us to detect it earlier.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Diagnosis of Juvenile Myoclonic Epilepsy in accordance with Consensus criteria * Age of myoclonus onset 10-25 years * Seizures comprising predominant or exclusive early morning myoclonus of upper extremities * EEG interictal generalized spikes and/or polyspike and waves with normal background * Current age 10-40 years Exclusion Criteria: * Myoclonus only associated with carbamazepine or lamotrigine therapy * EEG showing predominant focal interictal epileptiform discharges or abnormal background * Any evidence of progressive or symptomatic myoclonus epilepsy or focal seizures * Global learning disability * Dysmorphic syndrome * Unable to provide informed consent Regrettably, we are currently unable to accept self-referrals to the BIOJUME study.
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What it tests

  • Blood draw
  • Existing samples
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Where

15 sites
Mount Sinai-Beth Israel Medical Center
New York, United States
St Luke's Roosevelt Hospital
New York, United States
Nationwide Children's Hospital
Columbus, United States
Hospital for Sick Kids
Toronto, Canada
Charles University
Prague, Czechia
Danish National Epilepsy Centre
Dianalund, Denmark
Tallinn Children's Hospital
Tallinn, Estonia
University Robert Debré
Paris, France

…and 7 more on ClinicalTrials.gov.

🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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