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Vasopressin and Pain Perception in the Brain

RecruitingPhase 1, Phase 2Ages 18 Years - 65 YearsAllUniversity of Maryland, Baltimore
NCT03446456 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The feeling of pain is not just a sensory experience, but is also influenced by emotions, beliefs and expectations, making pain a highly subjective experience. This is evident in clinical practice, where the behavior of the physician and the treatment context can strongly influence the pain experience of patients. Research has shown that patients' expectation that a treatment will reduce pain influences individual perception of pain, even if the treatment has no active ingredient. The expectancy-induced analgesia emerges due to a modulation of the individual pain experience of patients by an engagement of endogenous inhibitory systems in the central nervous system. The development of expectancy-induced analgesia can be generated in several ways. The investigators have previously demonstrated that social information and observational learning (e.g. the patient observes analgesia in anoth

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📋 Eligibility rules (as published)
Inclusion Criteria: * Age ( 18-55 years old) * English speaker (written and spoken) Exclusion Criteria: * Cardiovascular, neurological diseases, pulmonary abnormalities, kidney disease, liver disease, degenerative neuromuscular disease, history of cancer within past 3 years * Any history of chronic pain disorder or currently in pain * Severe psychiatric condition (e.g. schizophrenia, bipolar disorders, mania, autism) and /or psychiatric condition leading to treatment and/or hospitalization within the last 3 years. * Family (first degree) history of mania, schizophrenia, or other psychoses * Lifetime alcohol/drug dependence or alcohol/drug abuse in past 3 months * Pregnancy or breast feeding * Color-blindness * Impaired, uncorrected hearing * History of angioedema * High blood pressure (above 140 mmHg) or symptomatic low blood pressure * History of fainting * Left handed * Allergies or sensitivities to creams, lotions or food coloring * Any non-organic implant or any non-removable metal device (e.g. pacemaker, cochlear implants, stents, surgical clips, non-removable piercings) * Any prior eye injury or the potential of a foreign body in the eye (e.g. worked in metal fields)Persisting functional impairment due to a head trauma * Fear of closed spaces * Any other contraindications for MRI (e.g. large tattoos on head and neck) * Previously participated in a "Pain Perception in the Brain" Study * Failed drug test (testing for opiates, cocaine, methamphetamines, amphetamines and THC)
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What it tests

  • Arginine vasopressin
  • Saline
  • Observational learning
  • fMRI data aquisition
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Where

1 site
Luana Colloca
Baltimore, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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