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โ† Trials
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rTMS for Craving in Methamphetamine Use Disorder

RecruitingNAAges 18 Years - 65 YearsAllOregon Health and Science University
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In plain words

What the trial is, and whether it could suit you

The primary aim of this project is to use a randomized single-blind sham-controlled study to investigate if high frequency repetitive transmagnetic stimulation (HF-rTMS) can modulate cue-induced craving in adult methamphetamine (METH) users. The investigators hypothesize that HF-rTMS directed at left dorsolateral prefrontal cortex (DLPFC) will result in a reduction in craving for METH compared to sham-controlled rTMS in adults with methamphetamine use disorder (MUD) as evidenced by validated measures of METH craving. Neurobiologically, the investigators anticipate rTMS mediated stimulation of the DLPFC could result in inhibition of cue-induced craving through potential disruption of involved circuitry. The current project proposes that participants who are recently abstinent from METH will be randomized into four experimental groups to provide two rTMS conditions (real versus sham) and t

Sign in to get the eligibility rules as simple questions to take to your doctor.

๐Ÿ“‹ Eligibility rules (as published)
Inclusion Criteria: * Subjects must use at least 0.5 g per day at least 5 days per week and have a minimum 12-month history of METH abuse. * Subjects must meet DSM V diagnosis for methamphetamine use disorder. * Subjects must have a minimum 4-week period of detoxification and a desire to stop using methamphetamine. Exclusion Criteria: * Present or past history of neurological disorder * The present history of a DSM IV Axis I or DSM V primary psychiatric disease (apart from MUD and depressive symptoms defined as a Hamilton Depression Scale Score \< 7 ("normal")) * Scores on the Hamilton Depression Scale \> 8, possibly indicating clinical depression * No current abuse of drugs other than methamphetamine (except nicotine). Urine-screening tests for psychoactive drugs will be performed to corroborate the lack of drug use. * Individuals meeting criteria for cannabis use disorder or alcohol use disorder * Medical illness that can affect brain function * Past or present history of cardiovascular disease or high blood pressure * Any history of epilepsy or a known history of seizure disorder * A history of metal in the head or chest area (except dental fillings or braces) * Current consumption of psychiatric medication * Any other medical, neurological or neurosurgical condition that would preclude the administration of repetitive transmagnetic stimulation
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What it tests

  • Real Repetitive transcranial magnetic stimulation
  • Sham Repetitive transcranial magnetic stimulation
  • Methamphetamine visual cues
  • Neutral visual cues
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Where

1 site
Veterans Affairs Portland Health Care System
Portland, United States
๐Ÿค Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible โ€” always decide together with your own doctor.
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