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Living Donor Liver Transplantation With Two Stage Hepatectomy for Patients With Isolated, Irresectable Colorectal Liver Metastases

RecruitingNAAges 18 Years - anyAllJena University Hospital
NCT03488953 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Nearly one third of patients with colorectal cancer develop liver metastases. It is well known that the achievement of a R0-situation is one of the most important factors for a positive long-term outcome. Despite further advantages in multimodal treatment concepts, only 20 - 30 % of the patients with metastases can be resected in curative intention. Recent studies, especially from Norway, have shown that liver transplantation might be a feasible option in well selected patients since the complete hepatectomy with subsequent liver transplantation can be an option for the achievement of a R0 situation. In this study, we pursue the strategy of two-stage hepatectomy combined with a left-lateral living donor liver transplantation. Inclusion criteria are as follows: non-resectable liver metastases of a primary colorectal carcinoma with an assumed portal-venous drainage of the tumor and at l

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with irresectable colorectal liver metastases without extrahepatic tumor burden, except resectable pulmonary metastases * stable disease or regression after at least eight weeks of systemic chemotherapy Exclusion Criteria: * comorbidities precluding liver transplantation * extrahepatic tumor spread, except resectable pulmonary metastases * progression during chemotherapy
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What it tests

  • Living donor liver transplantation with two-staged hepatectomy.
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Where

2 sites
Jena University Hospital
Jena, Germany
University Hospital Tübingen
Tübingen, Germany
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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