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Exercise Training and Endothelial Function in Type 1 Diabetes

RecruitingNAAges 18 Years - 50 YearsAllUniversity Hospital, Lille
NCT03528226 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Endothelial dysfunction and vasoreactivity disorders are early subclinical complications of type 1 diabetes (T1D). In a preventive setting, in T1D patients still free of complications, the research of non-pharmacological interventions to improve endothelial function appears fundamental. In this randomized controlled trial, the effects of exercise training on endothelial function will be evaluated in T1D adults. Secondary objectives are to evaluate the exercise training effects on the micro and macrovascular function and exercise-induced tissue vasoreactivity and their possible neurometabolic consequences. An improvement in vascular function, particularly endothelium-dependent, as well as in neurometabolic profile, through this non-pharmacological strategy is expected

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📋 Eligibility rules (as published)
Inclusion Criteria: * Covered by social security * With a T1Diabete, diagnosed for at least 1 year, and free from macrovascular and microvascular diabetic complications. Exclusion Criteria: * type 1 diabetes diagnoses for less than 1 year * MODY diabetes, mitochondrial diabetes or type 2 diabetes * presence of macrovascular and/or microvascular diabetic complications (retinopathy, nephropathy, neuropathy ,…) * Obesity (Body Mass Index \> 30 kg/m² * Smokers * Hypertension * Disabling painful discomfort for trunk, upper or lower limb movements * Active chronic disease or in remission (excluding type 1 diabetes) * Head trauma in the past
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What it tests

  • Exercise Training Procedure
  • Normal life procedure
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Where

1 site
Hop Claude Huriez Chu Lille
Lille, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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