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Tumour Regulatory Molecules in Early Pancreatic Cancer Detection

Recruitingn/aAges 18 Years - anyAllHull University Teaching Hospitals NHS Trust
NCT03536793 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The effective diagnosis of pancreatic cancer is often quite challenging, due to a lack of disease-specific symptoms, resulting in the majority of patients presenting with advanced disease, with an associated dismal prognosis. Earlier detection of pancreatic cancer, at a stage where surgery is feasible, would greatly increase the 5-year survival rate. Detecting pancreatic cancer early is therefore vital to improve the prognosis for these patients. Pre-cancerous pancreatic cysts are an early indicator of malignant transformation. The ideal screening test would be capable of detecting pancreatic cancer at these initial stages. Current procedures for pancreatic cancer diagnosis are invasive, uncomfortable and costly, and can be considered unnecessary in those cysts found to be benign. We propose to study a number of tumour regulatory molecules that have been the subject of research in labo

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📋 Eligibility rules (as published)
Inclusion Criteria: General * Capable of giving written informed consent * Age ≥18 years Pancreatic Cancer Cohort \- Diagnosed with localised pancreatic cancer amenable to resection (distal pancreatectomy, total pancreatectomy or Whipple's procedure). OR - Diagnosed with inoperable localised pancreatic cancer and referred for further management (malignant control subgroup). Pancreatic Cysts Cohort \- Presence of cystic lesions where MDT have agreed further diagnostic intervention procedures (including FNA/EUS) necessary. OR - Patient the MDT have agreed have resectable lesions suspicious for pancreatic malignancy and going to surgery. Benign Cohort \- Referral for endoscopic cystogastrostomy for complicated acute pancreatitis characterised by peripancreatic fluid collections and pseudocysts in development or matured (non-resolving and requiring further intervention). OR * Referral for cholecystectomy for cholocystitis/chololethiasis. OR * Patient planned to have endoscopy investigation for dyspepsia (normal control subgroup). Exclusion Criteria: General * Inability to provide written informed consent * Other known malignant condition, either active or in complete remission ≤5 years * HIV, hepatitis C, or any other known communicable disease
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What it tests

  • Not listed
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Where

1 site
Castle Hill Hospital, Hull University Teaching Hospitals NHS Trust
Cottingham, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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