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Validating Novel, Non-contrast Cardiac MRI Imaging in Haemodialysis Patients

Recruitingn/aAges 18 Years - anyAllUniversity of Leicester
NCT03586518 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

There are currently no good ways of measuring levels of scarring in the hearts of patients with advanced kidney disease and patients on dialysis, although recent research has shown a new cardiac MRI technique, called native T1 mapping, may provide a solution to this. To assess the accuracy of this novel technique in dialysis patients, it is essential to undertake a study which compares native T1 mapping to actual levels of scarring in the hearts of patients on dialysis.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Prevalent haemodialysis patient (more than 3 months) * Active on the supportive care register with anticipated death in the subsequent 12 months * Able to give informed consent * Consent to donation of heart for research following death * Able to understand written and verbal explanations in English Exclusion Criteria: * Contraindication to MRI scan (e.g. pacemaker, incompatible metallic implants, claustrophobia) * Patients with expected or potential infiltrative cardiomyopathy (e.g. amyloidosis) * Unable to give informed consent * Unable to understand written and verbal explanations in English
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What it tests

  • Cardiac MRI scan
  • Echocardiogram
  • Cardiac explantation
  • 48-Hour continuous cardiac monitoring
  • Blood samples
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Where

1 site
University Hospitals of Leicester NHS Trust
Leicester, United Kingdom
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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