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Genetic Counselling in the Prevention of Mental Health Consequences of Cannabis Use

RecruitingNAAges 12 Years - 21 YearsAllNova Scotia Health Authority
NCT03601026 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Severe mental illness (SMI) refers to the most burdensome psychiatric conditions. The need to pre-empt the onset of SMI is pressing because once SMI develops, quality of life is poor and available treatments have limited efficacy. Most risk factors for SMI are either unchangeable (e.g., genetics) or difficult to alter (e.g., low socio-economic status). In contrast, cannabis use is one specific risk factor that could be avoided. Certain individuals are more vulnerable to the harmful effects of cannabis. Genetic factors can help us identify these high-risk individuals. One in three individuals are carriers of a higher-risk genetic variant, and cannabis users with this genotype are at up to 7-fold increased risk of developing schizophrenia. In our study, genetic counselling will be provided to participants by a board-certified genetic counsellor. During the genetic counselling session, part

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📋 Eligibility rules (as published)
Inclusion Criteria: * Enrolment in the Families Overcoming Risks and Building Opportunities for Well-being (FORBOW) study. * Age between 12 and 21 years. * Knowledge of English sufficient to benefit from the intervention. * Capacity to provide informed consent at most recent FORBOW assessment. * Provision of consent to be contacted about future studies at most recent FORBOW assessment. Exclusion Criteria: * A diagnosis of severe mental illness (psychotic disorder, bipolar disorder, severe/recurrent depression) at baseline * Autism or intellectual disability of a degree that interferes with assessment (IQ \< 70)
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What it tests

  • Genetic counselling
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Where

1 site
Nova Scotia Health Authority
Halifax, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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