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Josef Ressel Centre Perinatal Programming

Recruitingn/aAges 18 Years - 50 YearsAllMoenie van der Kleyn
NCT03634930 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Background: Metabolic imprinting through early childhood nutrition seems to play an important role in the aetiology of obesity. Overweight at age two and later in life is associated with excessive weight gain as early as three months of age. Breastfeeding in the first year of life appears to be protective against obesity development. Objective: of the "Josef Ressel Centre for Early Life Metabolic Programming of Dispositions of Obesity" is to identify maternal and infant predictors of metabolic risk of obesity. The main considerations of modifiable factors are early infant nutrition, 24-hours-drinking-volume, the velocity of infant weight gain, in relation to infant fat mass and fat free mass, to biomarker and to the nutritional status of the mother. A second focus is put on maternal feeding style, infant eating behaviour and the identification of satiety cues. Multi-Study design: a mon

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. Pregnancy or mother in puerperium 2. Delivery of baby at 37+0 to 41+6 gestational age 3. Legal age (18 years old), age limit 50 years 4. Written consent of test person after having been informed 5. BMI ≥ 18.5 kg/m² to \< 30 kg/m² 6. Negative result of oGTT (oral glucose tolerance test) during pregnancy 7. Birth weight of baby 2.5-4.5 kg 8. Non-smoker since knowledge of pregnancy 9. Very good knowledge of German language and Caucasian 10. Exclusive breastfeeding or exclusive formula feeding at MR 2 (4th week of life) Exclusion Criteria: 1. Birth before 37+0 week of pregnancy (WoP) or after the 41+6 WoP 2. Multiple pregnancy 3. Children with serious congenital malformations of * Nervous system * Mouth, throat, neck * Circulation system * Respiratory tract * Gastrointestinal tract * Urogenital tract * Chromosomal aberrations 4. Diseases or hospitalization or intensive medical care of child during neonatal period 5. Hereditary metabolic diseases of child * Hereditary disorders of fat metabolism (MCHAD: Medium Chain Acyl-CoA Dehydrogenase Deficiency, LCHAD: Long Chain Acyl-CoA Dehydrogenase Deficiency, VLCHAD: Very Long Chain Acyl-CoA Dehydrogenase Deficiency) * Hereditary disorders of amino acid metabolism (PKU: Phenylketonuria) * Hereditary disorders of carbohydrate metabolism (Glycogenosis, Galactosemia, Hereditary fructose intolerance, Diabetes mellitus Type 1) 6. Drug (tobacco) abuse 7. Mental illnesses that have to be treated with medicaments 8. Metabolic or autoimmune diseases of mother 9. Complications at birth (blood loss \> 1000 ml or eclampsia) 10. Pre-conceptional diabetes (type 1 or 2) 11. Celiac disease and/or wheat protein allergy of mother 12. Breast surgery and/or hypomastia 13. Mixed feeding at MR 2 (4th week of life)
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What it tests

  • observation
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Where

1 site
FH Joanneum, university of applied sciences
Graz, Austria
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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