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Autologous Platelet-rich Plasma in the Treatment of Persistent Epithelial Defects

RecruitingNAAges any - anyAllUniversidad Autonoma de Nuevo Leon
NCT03653650 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Persistent epithelial defects (PED) are corneal ulcers that do not heal within the first two weeks of treatment with artificial tears or ocular lubricant ointment. It is believed that this condition is the result of the loss of certain substances normally present in the tears that aid in the healing process of the cornea. When the eye is healthy, these ulcers typically heal rapidly. However, when there is an underlying disease such as diabetes, this healing process is altered and it takes longer for the ulcer to heal. Autologous platelet-rich plasma (PRP) is a substance that is obtained from the patient's own blood and it is believed this substance may replace those missing factors in the tears of patients with PED. The purpose of this investigation is to find out whether PRP combined with a bandage contact lens is better than preservative free lubricant combined with bandage contact len

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients with persistent epithelial defect and at least one of the following diagnoses: * Recurrent corneal epithelial defect. * Neurotrophic corneal ulcer. * Neurotrophic keratopathy secondary to any disease (i.e. diabetes mellitus, infection with herpes simplex virus or herpes zoster virus, microbial keratitis sequelae, multiple sclerosis, Parkinson's disease, VII cranial nerve palsy, chemical or thermic burn sequelae, trauma, surgery, iatrogenic, chronic dry eye, rheumatic disease). Exclusion Criteria: * Patients diagnosed with: * Peripheral ulcerative keratitis, or Mooren's ulcer. * Active infectious keratitis and/or ulcers.
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What it tests

  • PRP plus BCL
  • BCL plus PFL
  • Eye patch plus ocular lubricant ointment
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Where

1 site
Departamento de Oftalmologia, Hospital Universitario "Dr. Jose Eleuterio Gonzalez"
Monterrey, Mexico
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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