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Riluzole in Patients With Spinocerebellar Ataxia Type 7

RecruitingPhase 2, Phase 3Ages 7 Years - anyAllS. Andrea Hospital
NCT03660917 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Spinocerebellar ataxia type 7 (SCA7) belongs to the dominant forms of inherited cerebellar ataxias (CA), being one of the rarest form. SCA7 has no therapeutic options, so that the relentless course, the important visual deficit that accompanies CA, and the possibility of disease development in childhood are pressing unmet needs. The investigators published encouraging data on riluzole in inherited CA other than SCA7. These results prompted off-label use of riluzole in single cases of SCA7 in Italy and United States, suggesting possible efficacy of the drug in this condition.

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📋 Eligibility rules (as published)
Inclusion Criteria: * positive genetic test for SCA7. Exclusion Criteria: * cardiac arrhythmias; * haematologic diseases; * hepatic diseases with serum values of alanine aminotransferase, aspartate aminotransferase or bilirubin \> 1·5 times above normal limit; * pregnancy (women of childbearing potential agreed to use contraception); * breastfeeding.
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What it tests

  • Riluzole
  • Placebo
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Where

1 site
Neurological Unit, S. Andrea Hospital, Faculty of Medicine and Psychology, "Sapienza" University of Rome
Rome, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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