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Modulating Inhibitory Control Networks in Gambling Disorder With Theta Burst Stimulation

RecruitingPhase 3Ages 18 Years - 65 YearsAllCNS Onlus
NCT03669315 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In this project the investigators propose a randomized double-blind placebo-controlled design in which 40 patients with GD will receive active or sham cTBS to the pre-SMA for 2 weeks. The investigators will combine TMS, multimodal structural and functional MRI and behavioral measures in order to identify circuit-level mechanisms of action and therapeutic targets (connectivity changes that explain clinical improvement) and assess the efficacy of TMS in modulating inhibitory control and symptom severity in this population.

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📋 Eligibility rules (as published)
Inclusion Criteria: 1. DSM-5 diagnosis of Gambling Disorder 2. Age between 18 and 65 years Exclusion Criteria: 1. any additional current psychiatric comorbidity, except for nicotine addiction; 2. a lifetime DSM-5 diagnosis of schizophrenia or other psychotic syndromes, substance dependence or substance abuse, including alcohol, bipolar I or II disorder, mental disorder due to a general medical condition; 3. serious suicide risk; 4. illness duration less than two years; 5. hospitalization in the last 6 months; 6. the inability to receive TMS because of metallic implants, or history of seizures (personal or family history of seizure in first degree relatives); 7. any major medical disease; 8. pregnancy or nursing of an infant; 9. the inability or refusal to provide written informed consent.
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What it tests

  • Transcranial Magnetic stimulation
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Where

1 site
CNSOnlus, Institute of Neuroscience
Florence, Italy
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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