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A Pilot Trial of Disposable Nitrous Oxide Canisters in Providing Pain Control During Burn Dressing Changes

RecruitingEARLY Phase 1Ages 18 Years - anyAllUniversity of Manitoba
NCT03695887 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Improvements in burn care have resulted in increased survival. Despite these improved outcomes one of the leading challenges of burn care remains providing adequate analgesia during routine wound care and dressing changes. The traditional use of narcotics is challenging as the therapeutic window between analgesia and suppression of breathing becomes narrow with the intense pain and high doses of narcotics needed for dressing changes.

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📋 Eligibility rules (as published)
Inclusion criteria * adult burn patients admitted to the Health Sciences Centre * total body surface area burned of 5-20% Exclusion criteria * admitted to intensive care unit * unable to participate in the measurement outcomes (sedated, cognitively impaired, unable to understand English or visually impaired) * medical condition that precludes using nitrous oxide (respiratory disease and significant cardiovascular disease 5). * pregnant * physically unable to hold the canister * \<90% SaO2 on room air * face burn * pre-injury narcotics (relative exclusion) * use of IV ketamine * pre-existing lung injury
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What it tests

  • Nitrous Oxide Inhalant Product
  • Placebo
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Where

1 site
University of Manitoba
Winnipeg, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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