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Peri-Procedural Transmural Electrophysiological (EP) Imaging of Scar-Related Ventricular Tachycardia

RecruitingNAAges 18 Years - 85 YearsAllJohn Sapp
NCT03713866 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Ventricular tachycardia (VT) contributes to over 350,000 sudden deaths each year in the US. Malignant VTs involve an electrical "short circuit" in the heart, formed by narrow channels of surviving tissue inside myocardial scar. An important treatment is to use catheter ablation to "block" the channel that forms the circuit. Effective ablation requires imaging guidance to visualize the VT circuit relative to scar structures in 3D. Unfortunately, with conventional catheter mapping, up to 90% of the VT circuits are too short-lived to be mapped. For the 10% "mappable" VTs, their data are only available during ablation and limited to one ventricular surface. This inadequacy of functional VT data largely limits the knowledge about scar-related VT and ablation strategies, and reduces the ability of clinicians to identify ablation targets and assess ablation outcome. The central hypothesis of t

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📋 Eligibility rules (as published)
Inclusion Criteria: * One or more episodes of sustained monomorphic VT * Referred for catheter ablation * Previously implanted ICD * Signed the patient informed consent form * Able and willing to comply with all pre-, post-, and follow-up testing and requirements Exclusion Criteria: * Have estimated Glomerular Filtration Ratio (eGFR) less than 30 * Have a life expectancy less than 6 months or are listed for heart transplantation at time of inclusion * Are pregnant * Are on IV inotropic agents * Have any contraindication to catheter ablation (including but not limited to mechanical prosthetic aortic and mitral valves, known protruding Left Ventricular (LV) thrombus * New York Heart Association (NYHA) functional class IV * Had ST wave elevation myocardial infarction within \< 1 month * Unwilling or unable to undergo cardiac MRI scan AND unwilling or unable to undergo cardiac CT scan (e.g. contrast allergy).
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What it tests

  • EP Imaging and Testing
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Where

1 site
QEII HSC
Halifax, Canada
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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