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Diagnosis of Renal Osteodystrophy in Patients With Reduced Renal Function

Recruitingn/aAges 18 Years - anyAllDitte Hansen
NCT03716128 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

The aim of the study is to 1. To describe the bone morphology in patients with reduced renal function and high or low parathyroid hormone (PTH) respectively. 2. To investigate if the non-invasive method 18-Fluoride Positron Emission Tomography (18F-PET) can describe the bone turnover and reflect the bone histomorphologic changes 3. To investigate if non-oxidized PTH reflects bone turnover

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📋 Eligibility rules (as published)
Patients with reduced renal function: Inclusion Criteria: -≥ 18 years * estimated Glomerular Filtration Rate (eGFR) ≤ 20 ml/min/1,73m2 * PTH \< 150 pg/ml or PTH \> 300 pg/ml Exclusion Criteria: * ongoing malignancy * Allergy towards tetracyclin * Pregnancy Control Group: Inclusion Criteria: -≥ 18 years * eGFR \>= 60 ml/min * under examination for c prostata * Prostatic Specific Antigen (PSA) total \<40 µg/l Exclusion: * Former kidney disease * ionized calcium or PTH outside normal range * Known metabolic bone disease * treatment with anticoagulants * Disturbed thrombosis and hemostasis
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What it tests

  • 18F-PET
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Where

1 site
Herlev Hospital
Herlev, Denmark
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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