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Inflammatory Mediators of Acute Kidney Injury in Intensive Care

Recruitingn/aAges 18 Years - anyAllUppsala University
NCT03720860 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Acute kidney injury (AKI) affects more than 50% of patients admitted to the intensive care unit. The most common underlying cause is sepsis. Severe AKI in combination with sepsis is associated with high mortality. The mechanisms for sepsis-induced AKI are largely unknown. Our hypothesis is that the inflammatory response to an infection cause collateral damage to host tissue and contributes to the development of AKI. In this study we want to investigate the presence of novel inflammatory mediators in patients with sepsis, patients subjected to major surgery (sterile inflammation) and non-inflamed patients and correlate their levels with the risk for AKI.

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📋 Eligibility rules (as published)
Inclusion Criteria: Patients admitted to the intensive/post operative care unit * with septic shock or * post major surgery or * after intoxication with a chemical compund Exclusion Criteria: * Pregnancy or * Breast feeding or * Chronic kidney disease or * intoxication with nephrotoxic compund or * lack of informed consent
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What it tests

  • Not listed
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Where

1 site
Akademiska sjukhuset, Centraloperation
Uppsala, Sweden
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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