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LET Optimized IMPT in Treating Pediatric Patients With Ependymoma

RecruitingPhase 1Ages any - 22 YearsAllM.D. Anderson Cancer Center
NCT03750513 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

This phase I trial studies the side effects of linear energy transfer (LET) optimized image modulated proton therapy (IMPT) in treating pediatric patients with ependymoma. Radiation therapy such as LET optimized IMPT, uses proton beams to kill tumor cells and shrink tumors without damaging surrounding normal tissues.

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📋 Eligibility rules (as published)
Inclusion Criteria: * Previous pathologic confirmation of ependymoma, World Health Organization (WHO) grade II or III * Disease must be confined to the brain (no evidence of spread on MR imaging of the spine or on staging lumbar puncture) * Patient may not receive chemotherapy concurrent with radiation * Signed informed consent by patient and/or parents or legal guardian * Lansky performance status score of 50 -100 Exclusion Criteria: * Patients with previous radiation therapy to the brain * Ependymoma of the spine * Disseminated ependymoma requiring craniospinal radiation therapy * Pregnancy * Inability to undergo MR imaging * Inability to receive gadolinium-based contrast agent
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What it tests

  • Linear Energy Transfer-Optimized Intensity Modulated Proton Therapy
  • Quality-of-Life Assessment
  • Questionnaire Administration
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Where

2 sites
Massachusetts General Hospital Cancer Center
Boston, United States
M D Anderson Cancer Center
Houston, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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