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APACHE Cohort (A Psoriatic Arthritis CoHort)

Recruitingn/aAges 18 Years - 65 YearsAllAssistance Publique - Hôpitaux de Paris
NCT03768271 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Psoriatic arthritis (PsA) is a chronic inflammatory rheumatic disease, belonging to the wide spectrum of spondyloarthritis, but with the particularity to be associated with personal psoriasis or familial psoriasis. PsA can be a very disabling disease through progressive and irreversible joint damage. Long-term functional prognosis of patients with PsA is correlated with the presence and severity of the radiographic joint lesions of the disease. However, the proportion of patients who will develop those peripheral joint damages is not yet known and less over the factors which are associated/involved in such an aggressive pattern of the disease. Early identification of this subgroup of patients is particularly important for determining early "intensive" treatment, strict management with a Treat To Target approach, and identification of new treatments with a stronger structural effect. Th

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📋 Eligibility rules (as published)
Inclusion Criteria: * Women or men aged from 18 to 65 inclusive * First episode of peripheral arthritis in the last 12 months, authenticated by a rheumatologist * Psoriasis diagnosed by a practitioner or family history of psoriatic arthritis (first-degree relative \[parent or sibling\] or second degree relative) * Arthritis most likely recognized as a psoriatic arthritis by a rheumatologist (diagnostic confidence score : ≥ 7 out of 10) * Signed informed consent form * Affiliation to a social security system Exclusion Criteria: * Formal diagnostic of inflammatory rheumatism other than psoriatic arthritis * Treatment or history of treatment with a biomedicine * Patient receiving csDMARDS (methotrexate, sulfasalazine, or leflunomide) or apremilast treatment over the past year for rheumatological symptoms * Oral steroids in the last 4 weeks, above 10 mg/d of prednisone or with modified dosage * intravenous or intra articular steroids in the last 4 weeks * IRM contraindication * Cognitive, mental or psychic disorders impeding protocol accomplishment * Difficulties with French language understanding * Patient under tutorship or curatorship * Pregnancy
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What it tests

  • Not listed
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Where

3 sites
Henri-Mondor Hospital
Créteil, France
Lapeyronie Hospital
Montpellier, France
Saint Joseph Hospital
Paris, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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