Cardiac Dysfunction in Childhood Cancer Survivors

This prospective cohort study is nested within the Childhood Cancer Registry (ChCR), a national, population-based cancer registry that includes all children and adolescents in Switzerland who were diagnosed with cancer at age 0-20 years. It includes patients diagnosed with leukemia, lymphoma, central nervous system tumors, and malignant solid tumours or Langerhans cell histiocytosis. Childhood cancer survivors have survived at least 5 years from cancer diagnosis. Inclusion Criteria: * Registered in the ChCR * Formerly treated at the Department of Pediatric Hematology/Oncology of one of five participating centers * Treated with any chemotherapy and/or chest radiation * Survived ≥ 5 years since most recent cancer diagnosis (primary cancer, relapse(s), secondary cancer) at time of examination * Diagnosed at age ≤ 20 years * ≥ 18 years of age at time of study participation * Resident in Switzerland * Written informed consent Exclusion Criteria: * Study participants will be excluded if they do not meet the above mentioned inclusion criteria or refuse to participate in the study.