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Impact of Long Alimentary Limb or Long Biliary Limb Roux-en-Y Gastric Bypass on Type 2 Diabetes Remission in Severely Obese Patients.

RecruitingNAAges 18 Years - 60 YearsAllUniversity Hospital, Lille
NCT03821636 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

In patients with type 2 diabetes, Roux-en-Y gastric bypass (RYGB), which excludes a portion of the stomach and the proximal intestine from the alimentary circuit, improves glucose metabolism more rapidly and more extensively than is expected from weight loss. The mechanisms of this unique effect of gastrointestinal exclusion appear to be complex and have not yet been clarified. A recent study unveil that intestinal uptake of ingested glucose is diminished by RYGB and restricted to the common limb, where food meets bile and other digestive fluids, resulting in an overall decrease of post prandial blood glucose excursion. the hypothesize that reducing the length of the common limb, which is rarely measured and highly variable in clinical practice, may significantly affect the metabolic outcome of gastrointestinal surgical procedures. The aim of the present study is to compare the impact of

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📋 Eligibility rules (as published)
Inclusion Criteria: * BMI ≥ 35 kg/m2 * All patient with type 2 diabetes * Patients who were candidates for obesity surgery in accordance with French recommendation Exclusion Criteria: * Severe cognitive or mental disorders * patient who have already undergone obesity surgery * Severe and non-stabilised eating disorders * The likely inability of the patient to participate in lifelong medical follow-up * Alcohol or psychoactive substances dependence * The absence of identified prior medical management of obesity * Diseases that are life-threatening in the short and medium term; * Contraindications to general anaesthesia.
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What it tests

  • Standard Roux-en-Y gastric bypass
  • Long alimentary limb Roux-en-Y gastric bypass
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Where

4 sites
Chu Amiens Picardie
Amiens, France
Ch Boulogne-Sur-Me
Boulogne-sur-Mer, France
Hop Claude Huriez Chu Lille
Lille, France
Ch de Valenciennes
Valenciennes, France
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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