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Bright Light Exposure in Surgical Patients

RecruitingNAAges 18 Years - 90 YearsAllUniversity of Colorado, Denver
NCT03822949 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

1. Elucidate the influence of intense light therapy pretreatment in patients undergoing cardiac surgery. We hypothesize that intense light exposure is associated with the peripheral stabilization of Per2 in human buccal swabs and plasma samples before surgery and with a decrease of Troponin I levels after surgery. In addition, we hypothesize that light therapy leads to Per2 dependent metabolic optimization in the human cardiac tissue. Therefore, a small piece of human heart tissue from the right atrium will be collected during cardiac cannulation, which will be otherwise discarded. 2. Critical illness (being in the intensive care unit) results in circadian malfunction and vessels not working. Vessel function is controlled by the body's circadian clock. Intense light boosts the circadian clock and the vessel function in animal studies. Vessels not working well in critical ill patients res

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📋 Eligibility rules (as published)
Inclusion Criteria: * Patients undergoing primary sternotomy cardiac surgery * Subjects in the range of 18 - 90 years old . * Patient need to be in sinus rhythm at the time of surgery. Exclusion Criteria: * patients \<18 or \>90 years old * participation in other clinical trials within the previous 30 days * pregnancy * neurological conditions that could impair weaning from ventilator support * significant CNS disorders or comorbid irreversible conditions with a six-month mortality rate more than 50 percent * prisoners, or subjects with altered capabilities to make decision will be enrolled * medical history of type 2 diabetes * patients with atrial fibrillation or use of class III anti-arhythmic drug * patients with a left ventricle ejection fraction \< 40% * patient in emergency condition
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What it tests

  • Day Light
  • Placebo light
  • ICU Intense Light
  • ICU Placebo light
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Where

1 site
University of Colorado Denver | Anschutz Medical Campus
Denver, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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