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Cell Free DNA in Cardiac Sarcoidosis

RecruitingNAAges 18 Years - anyAllNabeel Hamzeh
NCT03858777 on ClinicalTrials.gov ↗
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In plain words

What the trial is, and whether it could suit you

Sarcoidosis is a multisystem granulomatous disease of unknown cause that can affect any organ in the body, including the heart. Granulomatous myocarditis can lead to ventricular dysfunction and ventricular arrhythmias causing significant morbidity and mortality. Immunosuppressive therapy (IST) has been shown to reverse active myocarditis and preserve left ventricular (LV) function and in some cases improve LV function. In addition, IST can suppress arrhythmias that develop due to active myocarditis and prevent the formation of scar. The potential role of cardiac biomarkers, including brain natriuretic peptide (BNP), atrial natriuretic peptide (ANP), and cardiac troponins, in detecting active myocarditis is limited and studies have been disappointing. At present, there are no biomarkers to detect active myocarditis and the use of advanced imaging modalities (FDG-PET) for assessing and mo

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📋 Eligibility rules (as published)
1. Sarcoidosis patients without evidence of active myocarditis: * Inclusion: * Diagnosis of sarcoidosis based on the ATS/ERS criteria. * Normal 12 lead ECG within the past one year. * Non-smoker. * No immunosuppressive therapy for at least one year. * Exclusion: * Known cardiac disease. * Active smoker. * On immunosuppressive therapy. 2. Sarcoidosis patients with evidence of active myocarditis: * Inclusion: * Diagnosis of sarcoidosis based on the ATS/ERS criteria. * Evidence of active myocarditis based on recent cMRI or cFDG-PET. * Non-smoker. * Exclusion: * Known cardiac disease other than sarcoidosis. * Active smoker. * On immunosuppressive therapy. 3. Acute ST elevation myocardial infarction (STEMI): * Inclusion: * Diagnosis STEMI based on 1mm ST elevation in 2 or more contiguous leads. * Symptom onset within 12 hours. * Undergoing cardiac intervention for acute coronary syndrome. * Able to consent for blood draw. * Exclusion: * Active smoker. * Hemodynamically unstable. 4. Healthy controls: * Inclusion: * No known cardiac disease. * No known cardiovascular risk factors: hypertension, diabetes. * Non-smoker.
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What it tests

  • cell free DNA
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Where

2 sites
University of Iowa
Iowa City, United States
University of Iowa
Iowa City, United States
🤝 Taking part is your choice, and you can leave at any time. Only the trial team can confirm you are eligible — always decide together with your own doctor.
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